Anti-Sickling Effect of Dietary Thiocyanate in Prophylactic Control of Sickle Cell Anemia
http://www.helppeoplenow.com/uploads/8/9/4/8/8948721/oji_agbai.pdf
This is a scientific article by Dr. Oji Agbai, the maker of Dioscovite, about the anti-sickling effects of Thiocyanate.
Visit Dr. Agbai's website by clicking here: http://dioscovite1.com/
Sickle Cell Anemia
http://www.helppeoplenow.com/sickle-cell-anemia.html
An informative article about Sickle Cell Anemia.
Sickle Cell Anemia
http://www.fullhealthsecrets.com/diseases/816-2/
In this article, Dr. Agatha M. Thrash recommends a natrual diet rich in folate, high in thiocyanate, and rich in whole foods (fruits and vegetables, discourages the use of opioids in the treatment of Sickle Cell, recommends a strict and consistent schedule, and natural remedy alternatives for pain crises.
Please scroll down the page to read her specific recommendations.
Subject: Hope for Sickle Cell Anemia
http://www.pathlights.com/nr_encyclopedia/hn101998.htm
An article from a Canadian magazine about how a mom used Thiocyanate rich foods to help her son with his Sickle Cell.
Below is a list of Thiocyanate rich foods listed in the article:
P.S. Foods Rich in Thiocyanate (according to Maureen Henry):
Increased Survival Rate of Sickle-Cell Erythrocytes After Treatment In Vitro with Sodium Cyanate
http://www.pnas.org/content/68/11/2791.full.pdf
Erythrocyte - a red blood cell that (in humans) is typically a biconcave disc without a nucleus. Erythrocytes contain the pigment hemoglobin, which imparts the red color to blood, and transport oxygen and carbon dioxide to and from the tissues.
Effects of Urea and Cyanate on Sickling in Vitro
http://www.nejm.org/doi/full/10.1056/NEJM197207132870201
The Effects of Cyanate In Vitro on Red Blood Cell Metabolism and Function in Sickle Cell Anemia
http://www.jci.org/articles/view/106845
Traditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria
https://www.hindawi.com/journals/anemia/2012/607436/
Below is an excerpt from the article "Traditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria", denoting how Prickly Ash Bark has been used successfully in the treatment of Sickle Cell:
Doctors in Nigeria use fagara (F. zanthoxyloides) to reduce the painful crisis of the genetic disease, sickle cell anemia. This herb has a variety of unusual properties that reduce platelet and blood cell sticking. After reading the reports from Nigeria many years ago, I decided to try fagara’s relative prickly ash bark for the same indication. I made a simple tincture of 50% prickly ash bark and 50% ginkgo leaf, and gave it to a young African-American girl in the first grade who constantly missed school and needed to be hospitalized 3-4 times per year due to the painful sickle cell crisis. I gave her about 25 drops three times a day. She immediately stopped having serious problems, her thinking was no longer fuzzy, the frequency of her attacks went down to about one per year, and the severity of the attacks decreased appreciably. This success has continued through the years, as long as she takes her medicine. I saw her last year, and she has blossomed into a beautiful junior high school student, the sickle cell disease now only a bit-player in the background of her life. Another of my patients had lived with the disease his entire life, with almost constant pain, and bimonthly crisis. I gave him 35 drops three times per day, and he immediately improved in the same way as the young girl. This improvement in both frequency of attacks and level of pain has persisted in three of my long-term patients over many years. The wholesale cost of this medicine is less than $20 per month at full dosage. My biggest fear is that this knowledge will be co-opted by a pharmaceutical company, and made available to the many suffering children only at an exorbitant cost.
Source: “PRICKLY ASH BARK (Zanthoxylum species),” An mhtm document by Dr. Tillotson of Tillotson Institute of Natural Health, 2011.
https://www.hindawi.com/journals/anemia/2012/607436/
Dietary Thiocyanate Found Effective in Preventing Sickling
https://healingblendsglobal.net/2015/02/thiocyanate-found-effective-preventing-sickling/
Excerpt:
The Potential of Medicinal Plants in Sickle Cell Disease Control: A Review
https://www.researchgate.net/profile/Olumide_Adebesin/publication/228479833_The_potential_of_medicinal_plants_in_sickle_cell_disease_control_A_review/links/0fcfd513d93628334c000000.pdf
Sickle Cell Anemia and Dietary Precursors of Cyanate
http://ajcn.nutrition.org/content/26/11/1261.shorthttp://ajcn.nutrition.org/content/26/11/1261.short
Comparative studies on antisickling properties of thiocyanate, tellurite and hydroxyurea
http://pjms.com.pk/issues/janmar08/article/article3.html
Niprisan for Treating Patients with Sickle Cell Disease
https://www.sbir.gov/sbirsearch/detail/352226
Below are two articles from a Nigerian internet forum, excerpted from the link below:
http://www.helppeoplenow.com/uploads/8/9/4/8/8948721/oji_agbai.pdf
This is a scientific article by Dr. Oji Agbai, the maker of Dioscovite, about the anti-sickling effects of Thiocyanate.
Visit Dr. Agbai's website by clicking here: http://dioscovite1.com/
Sickle Cell Anemia
http://www.helppeoplenow.com/sickle-cell-anemia.html
An informative article about Sickle Cell Anemia.
Sickle Cell Anemia
http://www.fullhealthsecrets.com/diseases/816-2/
In this article, Dr. Agatha M. Thrash recommends a natrual diet rich in folate, high in thiocyanate, and rich in whole foods (fruits and vegetables, discourages the use of opioids in the treatment of Sickle Cell, recommends a strict and consistent schedule, and natural remedy alternatives for pain crises.
Please scroll down the page to read her specific recommendations.
Subject: Hope for Sickle Cell Anemia
http://www.pathlights.com/nr_encyclopedia/hn101998.htm
An article from a Canadian magazine about how a mom used Thiocyanate rich foods to help her son with his Sickle Cell.
Below is a list of Thiocyanate rich foods listed in the article:
P.S. Foods Rich in Thiocyanate (according to Maureen Henry):
- african yam, alfalfa sprouts, apricot, bamboo shoot,
- banana, bitter almond, broccoli, Brussels sprouts,
- buckwheat, buffalo berry, cabbage, carrot,
- cassava, cauliflower, cherry, chickpea,
- cloudberry, elderberry, flaxseed, kohlrabi,
- lentils, lima bean, macadamia nuts,
- millet, mustard green, peaches, plantain,
- plums, radish sprouts, raspberry, red clover,
- rutabaga, salmonberry, sorghum, strawberry,
- turnips
Increased Survival Rate of Sickle-Cell Erythrocytes After Treatment In Vitro with Sodium Cyanate
http://www.pnas.org/content/68/11/2791.full.pdf
Erythrocyte - a red blood cell that (in humans) is typically a biconcave disc without a nucleus. Erythrocytes contain the pigment hemoglobin, which imparts the red color to blood, and transport oxygen and carbon dioxide to and from the tissues.
Effects of Urea and Cyanate on Sickling in Vitro
http://www.nejm.org/doi/full/10.1056/NEJM197207132870201
The Effects of Cyanate In Vitro on Red Blood Cell Metabolism and Function in Sickle Cell Anemia
http://www.jci.org/articles/view/106845
Traditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria
https://www.hindawi.com/journals/anemia/2012/607436/
Below is an excerpt from the article "Traditional Herbal Management of Sickle Cell Anemia: Lessons from Nigeria", denoting how Prickly Ash Bark has been used successfully in the treatment of Sickle Cell:
Doctors in Nigeria use fagara (F. zanthoxyloides) to reduce the painful crisis of the genetic disease, sickle cell anemia. This herb has a variety of unusual properties that reduce platelet and blood cell sticking. After reading the reports from Nigeria many years ago, I decided to try fagara’s relative prickly ash bark for the same indication. I made a simple tincture of 50% prickly ash bark and 50% ginkgo leaf, and gave it to a young African-American girl in the first grade who constantly missed school and needed to be hospitalized 3-4 times per year due to the painful sickle cell crisis. I gave her about 25 drops three times a day. She immediately stopped having serious problems, her thinking was no longer fuzzy, the frequency of her attacks went down to about one per year, and the severity of the attacks decreased appreciably. This success has continued through the years, as long as she takes her medicine. I saw her last year, and she has blossomed into a beautiful junior high school student, the sickle cell disease now only a bit-player in the background of her life. Another of my patients had lived with the disease his entire life, with almost constant pain, and bimonthly crisis. I gave him 35 drops three times per day, and he immediately improved in the same way as the young girl. This improvement in both frequency of attacks and level of pain has persisted in three of my long-term patients over many years. The wholesale cost of this medicine is less than $20 per month at full dosage. My biggest fear is that this knowledge will be co-opted by a pharmaceutical company, and made available to the many suffering children only at an exorbitant cost.
Source: “PRICKLY ASH BARK (Zanthoxylum species),” An mhtm document by Dr. Tillotson of Tillotson Institute of Natural Health, 2011.
https://www.hindawi.com/journals/anemia/2012/607436/
Dietary Thiocyanate Found Effective in Preventing Sickling
https://healingblendsglobal.net/2015/02/thiocyanate-found-effective-preventing-sickling/
Excerpt:
Thiocyanate is a salt analogous in composition to
cyanate, but containing sulfur instead of oxygen; called also
sulfocyanate. This is a cultural ethnic food approach to
preventing the symptoms associated with Sickle Cell Disease. A
diet rich in nutritional Thiocyanate/Dioscovite has shown to be
effective in preventing the sickling of the red blood cells in
people with Sickle Cell Disease. It is not a cure but assist with
controlling the problems and symptoms associated with the
disease. The painful crisis of Sickle Cell Anemia is infrequent and
not as severe in people whose diet is rich in Thiocyanate/
Dioscovite. Dietary Thiocyanate is not only an anti-sickling
agent, it has antibiotic activity as well.
cyanate, but containing sulfur instead of oxygen; called also
sulfocyanate. This is a cultural ethnic food approach to
preventing the symptoms associated with Sickle Cell Disease. A
diet rich in nutritional Thiocyanate/Dioscovite has shown to be
effective in preventing the sickling of the red blood cells in
people with Sickle Cell Disease. It is not a cure but assist with
controlling the problems and symptoms associated with the
disease. The painful crisis of Sickle Cell Anemia is infrequent and
not as severe in people whose diet is rich in Thiocyanate/
Dioscovite. Dietary Thiocyanate is not only an anti-sickling
agent, it has antibiotic activity as well.
Sources of thiocyanate are: millet, buckwheat, lima beans, greens, cabbage, carrots, cashew nuts, cauliflower, strawberries, lentils, broccoli, chickpeas, plantain (a type of banana), sorghum, African yam and cassava.
Source: https://healingblendsglobal.net/2015/02/thiocyanate-found-effective-preventing-sickling/The Potential of Medicinal Plants in Sickle Cell Disease Control: A Review
https://www.researchgate.net/profile/Olumide_Adebesin/publication/228479833_The_potential_of_medicinal_plants_in_sickle_cell_disease_control_A_review/links/0fcfd513d93628334c000000.pdf
Sickle Cell Anemia and Dietary Precursors of Cyanate
http://ajcn.nutrition.org/content/26/11/1261.shorthttp://ajcn.nutrition.org/content/26/11/1261.short
Comparative studies on antisickling properties of thiocyanate, tellurite and hydroxyurea
http://pjms.com.pk/issues/janmar08/article/article3.html
Niprisan for Treating Patients with Sickle Cell Disease
https://www.sbir.gov/sbirsearch/detail/352226
Abstract
DESCRIPTION (provided by applicant): Sickle Cell Disease (SCD) is a
hereditary blood disorder caused by an abnormal hemoglobin called
sickle hemoglobin (Hb S). Although the Hb S of patients with SCD in the
steady state can transport oxygen like normal hemoglobin, Hb S forms
rigid fibers when the blood is exposed to hypoxia. The deoxy-Hb S fibers
push the red blood cell membrane toward the outside, causing
deformation of the cells to assume a sickle shape. Rigid sickled cells
cannot pass through narrow capillaries and they occlude blood vessels,
which may cause serious organ damage. Although the cause of SCD is well
known and more than 200,000 drugs have been screened, hydroxyurea is the
only drug that is currently available for the treatment of patients
with SCD. One problem with hydroxyurea, however, is that it is not
uniformly effective in all patients and some patients develop severe
adverse effects.
In an attempt to develop a new anti-sickling agent, Xechem, together
with researchers at the Children's Hospital of Philadelphia, PA,
proposes testing of a new phytopharmaceutical anti-sickling agent,
NIPRISAN, for the treatment of patients with SCD. NIPRISAN is the
extract of four kinds of plants in Africa and has been used in Nigeria
for the treatment of SCD for a long time. However, since it was not
studied scientifically and the remedies were prepared differently in
different areas, the drug has never been used in other countries.
Recently, the Nigerian government performed preliminary studies on
NIPRISAN and showed that oral administration of NIPRISAN led to a
significant reduction in the frequency of painful episodes. The
effectiveness of NIPRISAN was also studied at the Sickle Ceil Disease
Reference Laboratory at the Children's Hospital of Philadelphia, PA,
using transgenic (tg) sickle mice that produce human HbS.
The aim of this application is to prepare a novel, safe, standardized
drug that will be uniformly effective in patients with SCD with minimum
adverse effects. For this purpose, in the Phase 1 study, we will prepare
a standardized optimal formulation of NIPRISAN that will be easily
administered orally, has a consistent anti-sickling effect among
different lots, and maintains the maximum activity during the shelf
time. The development of an effective anti-sickling agent not only is
beneficial to patients with SCD and their families, but also will reduce
the financial burden on governments and healthcare systems. Below are two articles from a Nigerian internet forum, excerpted from the link below:
http://www.nairaland.com/
Thiocyanate: An All Natural Cure for Sickle Cell Anemia?
Anti-Sickling Medicine in African Yams and Cassava
By Ana Kirk
November 4, 2010
"The poor little thing is in for a rough life," were the words of the doctor in reference to the little boy whom I helped to attend under the guidance of my preceptor that night in the emergency room where I was doing my clinicals as an emergency medical technician student. This is the first time I really pondered the question of whether there is a cure for sickle cell anemia.
What Is Thiocyanate? Is It a Possible Cure for Sickle Cell Anemia?
Thiocyanate, sometimes called sulfocyanate or simply "yam vitamin" is a natural substance found in certain plants called nitrilosides among which are the foods African yams and cassava. These edible plants were once staples in the diet of native Africans before the introduction of grains such as rice and wheat. During the times when African yams and cassava were consumed as staples in Africa, sickle cell anemia was non-existent. These foods are still consumed in Africa, but in smaller quantities, and now sickle cell anemia exists there.
Is the consumption of plants such as the African yam and cassava a natural cure for sickle cell anemia? Some answer that question in the affirmative and view the disease as the consequences of a nutritional deficiency that disappears when the missing nutrient, thiocyanate, is provided in the diet. Fortunately, those who believe that there's a cure for sickle cell anemia also believe that African Americans, in addition to returning to some of the foods of the motherland, must also rid their diet of harmful "foods" and drinks that are destroying the health of all North Americans regardless of ethnic origin. If someone diagnosed with this disease never again had to endure sickle cell crisis, would it not be said that he found a cure?
Thiocyanate: The Anti-Sickling Nutrient
Sickle cell disease is characterized by crescent-shaped or sickled red blood cells and chronic anemia resulting from the abnormally high destruction of red blood cells. Thiocyanate has been proven to greatly reduce the sickling of red blood cells and it might completely prevent sickling in many individuals. In the case of the total prevention of sickling, many people would call this a "cure" for sickle cell anemia.
Scurvy is a disease caused by insufficient vitamin C in the diet. Who worries about developing scurvy as long as they eat some fruits? Beriberi is a disease caused by a deficiency of vitamin B1 (thiamin). Who worries about developing it in the U.S.A where foods are enriched with this nutrient? Pellagra is a disease caused by a deficiency of vitamin B3 (niacin). Again, who is concerned about developing pellagra since almost all foods are at least enriched with the nutrient?
Why face the great discomfort that can be experienced during a sickle cell crisis, the health risks of blood transfusions, pain killers, and life-threatening side effects of the drug hydroxyurea frequently used in treatment? Long term use of hydroxyurea has been linked to the development of cancerous tumors and leukemia.
Foods Rich in Thiocyanate
Those who will not cease to believe that there is a cure for sickle cell anemia will persist in following a diet high in organic iron, cleansing natural chlorophyll, and the all natural anti-sickling nutrient, thiocyanate. Foods and herbs high in natural iron include: green leafy vegetables such as greens and green leaf lettuce (not ice berg), yellow vegetables such as squash, whole grain products made from grains such as spelt, barley, millet, sorghum, kamut, and oats, legumes, lentils, kidney beans, dandelion, burdock, yellow dock root, strawberry fruit, kelp, cayenne and dulse. Good sources of chlorophyll are any of the green leafy vegetables such as greens and other vegetables such as bell pepper. African yam and cassava are believed to be the richest sources of thiocyanate; but, what if those foods aren't readily available? Other sources of thiocyanate are: millet, buckwheat, lima beans, greens, cabbage, carrots, cashew nuts, cauliflower, strawberries, lentils, broccoli, chickpeas, plantain (a type of banana), and sorghum. It's still a good idea, however, to continue looking for sources of African yam and cassava.
http://www.blackherbals.com/
Sickle Cell - a Nutritional Deficiency Disease?
by Elena N. Marcus
We have reached the end of September, the ‘sickle cell anemia month,’ without any exciting news in the field. Last December, the National Institute of Health stopped a clinical trial that tested the possibility of reducing the number of blood transfusions in children who are at risk of stroke. Norvalis had been testing a new iron chelator, ICL-670 and comparing it with one that is already on the market. Sickle cell patients often have to take iron chelators in order to remove the excess of this mineral caused by blood transfusions.
On the other hand, the news regarding the evidence that sickle cell crises can and have been avoided in clinical and epidemiological studies by administering a missing nutrient is almost three-quarter-century old. In an 1973 article in the American Journal of Clinical Nutrition, Robert Houston reviewed the evidence that sickle cell is a thiocyanate-deficiency disease, and expressed outrage that this evidence had been ignored for 40 years. And it is still ignored today by most those who suffer from the disease.
It has been known since the 19th century that sickle cell disease did not exist in Africa before Europeans penetrated this continent. The thiocyanate, present in plants called nitrilosides, such as cassava (manioc) and the African yam was abundant in diet staples of Africans. Cassava is a native of South America, and was introduced here in the 1600s. According to Houston, studies show that West Africans had more thiocyanate in their blood and saliva than African-Americans. According to researcher Oji Agbai, the sickle cell anemia is common now in his native regions of Northern Africa, among city dwellers who have replaced their native staples with rice and wheat. Incidentally, there is evidence that thiocyanate protects against cancer and high blood pressure as well. According to the National Institute of Health, African-American men are more likely to suffer from high blood pressure, and African American women have more virulent breast cancers than Americans of European descent. Thiocyanate found in foods such as broccoli is now recognized as an anti-cancer compound.
In the 1980s, anthropologist Fatima Linda Collier Jackson (then with the University of California at Berkeley), found a high incidence of sickle cell homozygous genotype (carrying two sickle cell genes) in regions of North Africa. Since it made no sense for carriers of genes that shorten life span to strive in a population, this finding forwarded the theory proposed by Linus Pauling a decade before, that sickle cell anemia is a nutritional deficiency diseases, in fact an adaptive condition. According to this theory, the sickle cell anemia protects the carrier against the malaria parasite, plasmodium falciparum. The parasite doesn’t strive well in blood, under conditions of scarce oxygen. However painful sickle cell crises may be, malaria is deadly. Before Jackson, anthropologist William H. Durham had previously studied the customs of West Africans and discovered that during the malaria season, strict religious decrees prevented locals from eating the thiocyanate-rich African yams even during food scarcity periods.
Jackson further administered thiocyanate to guinea pigs, and found that the substance caused carbamylation, an effect upon the blood cells which is salutary against sickling episodes.
Biochemist Oji Agbai ND, PhD from Tulsa, Oklahoma, author of Sickle Cell Anemia: A Solution at Last, has created a micronutrient compound that contains potassium thiocyanate (KSCN) together with iodine. In his self-published book, Agbai relates a clinical study in which the KSCN improved the condition of a patient whose veins were so riddled with needles, that blood transfusions could no longer be performed. He found that the KSCN prevented the red blood cells from becoming sickle-shaped and lessened the number of crises by making the blood more soluble, and by dilating the blood vessels.
Agbai, who is a descendant from the North African tribe Igbo, together with medical authorities in Niger, have successfully tested the benefits of KSCN in the sickle cell population in that country.
Furthermore, before many new 'improved' and newly patented pharmaceuticals for high blood pressure came on the market, potassium thyocianate was commonly administered during the 1930s to lower blood pressure.
About one in every 500 African-Americans have sickle cell anemia, a disease that is due to a tendency of blood cells to ‘ dry out’ and assume a sickle shape (instead of the usual circular form), leading to oxygen starvation, anemia, and severe pain. About one in 12 people of African descent have the sickle cell ‘trait,’ which means they carry a single gene for the condition. The condition may also be present among people from the Middle East, India, South America, and Jamaica.
Only those individuals who are born with double sickle cell ‘allele,’being therefore homozygote for sickle cell, may actually have blood cells that ‘sickle.’ The anemia is characterized by extremely painful crises, depression of the immune system, fatigue, and diseases derived from low immunity. The patients also suffer from adverse effects of modern treatments which are often invasive and dangerous. Blood transfusions and a drug called hydroxyurea are the most common palliative solutions. The first places the patients at risk of iron overload and strokes (especially children), and the second is a known carcinogen. The life expectancy of a sickle cell patients is 45 years, and the quality of life is considerably diminished.
In the 1970’s when Linus Pauling discovered the molecular basis of the sickle cell anemia, he contended it was a nutrient-deficiency disease. Houston and others have followed in his steps with numerous valid arguments, including clinical reports from the 1930’s and 1940s of the benefits of thiocianate in sickle cell blood. In his seminal article in which he lays out the evidence, both epidemiological and biochemical, Houston reviews the literature describing how Jamaicans who have immigrated to the United States have developed sickle cell anemia, a genetic ‘disease’ of which they had not even been aware. When some of these Jamaican natives returned to their island (and to their native diets) the sickle cell anemia crises subsided completely. Foods containing thiocyanate compounds are vegetables from the brassica family such as cabbage and broccoli, the seeds of most fruits, flax seeds, bitter almonds, the grain millet, and some pulses (beans). Africans have food preparation customs which lower the cyanate content of their staples, the cassava and African yam (no relation with potato), to safe levels.
Although currently it is studied as a anti-cancer micronutrient, thiocyanate suffered a bad rap due to the fact that, on its metabolic path in the body, it turns into cyanide. However, pure cyanide, a molecule of carbon and one of nitrogen united by a triple bond, has existed long before any life form existed on Earth. Human body, and other vertebrates as well, can handle minute amounts of this highly poisonous substance. In fact cyanide has a role in the synthesis of vitamin B12. After making use of it, the body turns the cyanide back into thiocyanate with the help of the enzyme rhodanide synthetase. Sufficient protein intake is needed for this conversion to take place. Additonally, individuals who eat thiocyanate-rich foods have to supplement with iodine.
There are dozens of plants containing thiocyanate or various compounds of cyanide, and one pioneer in revealing their health-giving properties, Ernst T. Krebs, has called them nitrilosides. Krebs, who contended that thiocyanate should be accepted as a vitamin (B17), researched animal diets as a student of zoology and found that most animals, including those living at the North Pole, have a thiocyanate source in the diet.
Sickle cell patients were found to be clinical deficient in many micronutrients, including the amino acid Arginine, the minerals zinc, magnesium and the B vitamins. Some studies show that these and other nutrients such as fish oil, and a combination of folic acid, aged garlic, l-Arginine, vitamins E and C have had beneficial effects on the health of these patients. The mineral zinc, for example, was found to reduce leg ulcers, which are often associated with sickle cell anemia, while the mineral magnesium pidolate was found to reduce the crises.
One of the most staunch promoter of nutrition awareness among sickle cell patients, Berkeley nutritionist and health writer Clara Felix reported repeatedly on the sickle cell and thiocyanate connection in her newsletter, “The Felix Letter, A Commentary on Nutrition.” She kept track relentlessly of all the efforts towards research in this direction. She also has described the cold shoulder that she encountered when she tried to bring Oji Agbai and other thiocyanate promoters to the attention of clinical practitioners, specifically at the Children's Hospital in Oakland. Clara Felix so wanted that those children (from the sickle cell ward at Oakland Children Hospital for example) benefit from her passionate research. In her memory, her son Elliot, has founded a non profit sickle cell section in his acupuncture clinic (http://www.clarafelixclinic.
Thiocyanate: An All Natural Cure for Sickle Cell Anemia?
Anti-Sickling Medicine in African Yams and Cassava
By Ana Kirk
November 4, 2010
"The poor little thing is in for a rough life," were the words of the doctor in reference to the little boy whom I helped to attend under the guidance of my preceptor that night in the emergency room where I was doing my clinicals as an emergency medical technician student. This is the first time I really pondered the question of whether there is a cure for sickle cell anemia.
What Is Thiocyanate? Is It a Possible Cure for Sickle Cell Anemia?
Thiocyanate, sometimes called sulfocyanate or simply "yam vitamin" is a natural substance found in certain plants called nitrilosides among which are the foods African yams and cassava. These edible plants were once staples in the diet of native Africans before the introduction of grains such as rice and wheat. During the times when African yams and cassava were consumed as staples in Africa, sickle cell anemia was non-existent. These foods are still consumed in Africa, but in smaller quantities, and now sickle cell anemia exists there.
Is the consumption of plants such as the African yam and cassava a natural cure for sickle cell anemia? Some answer that question in the affirmative and view the disease as the consequences of a nutritional deficiency that disappears when the missing nutrient, thiocyanate, is provided in the diet. Fortunately, those who believe that there's a cure for sickle cell anemia also believe that African Americans, in addition to returning to some of the foods of the motherland, must also rid their diet of harmful "foods" and drinks that are destroying the health of all North Americans regardless of ethnic origin. If someone diagnosed with this disease never again had to endure sickle cell crisis, would it not be said that he found a cure?
Thiocyanate: The Anti-Sickling Nutrient
Sickle cell disease is characterized by crescent-shaped or sickled red blood cells and chronic anemia resulting from the abnormally high destruction of red blood cells. Thiocyanate has been proven to greatly reduce the sickling of red blood cells and it might completely prevent sickling in many individuals. In the case of the total prevention of sickling, many people would call this a "cure" for sickle cell anemia.
Scurvy is a disease caused by insufficient vitamin C in the diet. Who worries about developing scurvy as long as they eat some fruits? Beriberi is a disease caused by a deficiency of vitamin B1 (thiamin). Who worries about developing it in the U.S.A where foods are enriched with this nutrient? Pellagra is a disease caused by a deficiency of vitamin B3 (niacin). Again, who is concerned about developing pellagra since almost all foods are at least enriched with the nutrient?
Why face the great discomfort that can be experienced during a sickle cell crisis, the health risks of blood transfusions, pain killers, and life-threatening side effects of the drug hydroxyurea frequently used in treatment? Long term use of hydroxyurea has been linked to the development of cancerous tumors and leukemia.
Foods Rich in Thiocyanate
Those who will not cease to believe that there is a cure for sickle cell anemia will persist in following a diet high in organic iron, cleansing natural chlorophyll, and the all natural anti-sickling nutrient, thiocyanate. Foods and herbs high in natural iron include: green leafy vegetables such as greens and green leaf lettuce (not ice berg), yellow vegetables such as squash, whole grain products made from grains such as spelt, barley, millet, sorghum, kamut, and oats, legumes, lentils, kidney beans, dandelion, burdock, yellow dock root, strawberry fruit, kelp, cayenne and dulse. Good sources of chlorophyll are any of the green leafy vegetables such as greens and other vegetables such as bell pepper. African yam and cassava are believed to be the richest sources of thiocyanate; but, what if those foods aren't readily available? Other sources of thiocyanate are: millet, buckwheat, lima beans, greens, cabbage, carrots, cashew nuts, cauliflower, strawberries, lentils, broccoli, chickpeas, plantain (a type of banana), and sorghum. It's still a good idea, however, to continue looking for sources of African yam and cassava.
http://www.blackherbals.com/
Sickle Cell - a Nutritional Deficiency Disease?
by Elena N. Marcus
We have reached the end of September, the ‘sickle cell anemia month,’ without any exciting news in the field. Last December, the National Institute of Health stopped a clinical trial that tested the possibility of reducing the number of blood transfusions in children who are at risk of stroke. Norvalis had been testing a new iron chelator, ICL-670 and comparing it with one that is already on the market. Sickle cell patients often have to take iron chelators in order to remove the excess of this mineral caused by blood transfusions.
On the other hand, the news regarding the evidence that sickle cell crises can and have been avoided in clinical and epidemiological studies by administering a missing nutrient is almost three-quarter-century old. In an 1973 article in the American Journal of Clinical Nutrition, Robert Houston reviewed the evidence that sickle cell is a thiocyanate-deficiency disease, and expressed outrage that this evidence had been ignored for 40 years. And it is still ignored today by most those who suffer from the disease.
It has been known since the 19th century that sickle cell disease did not exist in Africa before Europeans penetrated this continent. The thiocyanate, present in plants called nitrilosides, such as cassava (manioc) and the African yam was abundant in diet staples of Africans. Cassava is a native of South America, and was introduced here in the 1600s. According to Houston, studies show that West Africans had more thiocyanate in their blood and saliva than African-Americans. According to researcher Oji Agbai, the sickle cell anemia is common now in his native regions of Northern Africa, among city dwellers who have replaced their native staples with rice and wheat. Incidentally, there is evidence that thiocyanate protects against cancer and high blood pressure as well. According to the National Institute of Health, African-American men are more likely to suffer from high blood pressure, and African American women have more virulent breast cancers than Americans of European descent. Thiocyanate found in foods such as broccoli is now recognized as an anti-cancer compound.
In the 1980s, anthropologist Fatima Linda Collier Jackson (then with the University of California at Berkeley), found a high incidence of sickle cell homozygous genotype (carrying two sickle cell genes) in regions of North Africa. Since it made no sense for carriers of genes that shorten life span to strive in a population, this finding forwarded the theory proposed by Linus Pauling a decade before, that sickle cell anemia is a nutritional deficiency diseases, in fact an adaptive condition. According to this theory, the sickle cell anemia protects the carrier against the malaria parasite, plasmodium falciparum. The parasite doesn’t strive well in blood, under conditions of scarce oxygen. However painful sickle cell crises may be, malaria is deadly. Before Jackson, anthropologist William H. Durham had previously studied the customs of West Africans and discovered that during the malaria season, strict religious decrees prevented locals from eating the thiocyanate-rich African yams even during food scarcity periods.
Jackson further administered thiocyanate to guinea pigs, and found that the substance caused carbamylation, an effect upon the blood cells which is salutary against sickling episodes.
Biochemist Oji Agbai ND, PhD from Tulsa, Oklahoma, author of Sickle Cell Anemia: A Solution at Last, has created a micronutrient compound that contains potassium thiocyanate (KSCN) together with iodine. In his self-published book, Agbai relates a clinical study in which the KSCN improved the condition of a patient whose veins were so riddled with needles, that blood transfusions could no longer be performed. He found that the KSCN prevented the red blood cells from becoming sickle-shaped and lessened the number of crises by making the blood more soluble, and by dilating the blood vessels.
Agbai, who is a descendant from the North African tribe Igbo, together with medical authorities in Niger, have successfully tested the benefits of KSCN in the sickle cell population in that country.
Furthermore, before many new 'improved' and newly patented pharmaceuticals for high blood pressure came on the market, potassium thyocianate was commonly administered during the 1930s to lower blood pressure.
About one in every 500 African-Americans have sickle cell anemia, a disease that is due to a tendency of blood cells to ‘ dry out’ and assume a sickle shape (instead of the usual circular form), leading to oxygen starvation, anemia, and severe pain. About one in 12 people of African descent have the sickle cell ‘trait,’ which means they carry a single gene for the condition. The condition may also be present among people from the Middle East, India, South America, and Jamaica.
Only those individuals who are born with double sickle cell ‘allele,’being therefore homozygote for sickle cell, may actually have blood cells that ‘sickle.’ The anemia is characterized by extremely painful crises, depression of the immune system, fatigue, and diseases derived from low immunity. The patients also suffer from adverse effects of modern treatments which are often invasive and dangerous. Blood transfusions and a drug called hydroxyurea are the most common palliative solutions. The first places the patients at risk of iron overload and strokes (especially children), and the second is a known carcinogen. The life expectancy of a sickle cell patients is 45 years, and the quality of life is considerably diminished.
In the 1970’s when Linus Pauling discovered the molecular basis of the sickle cell anemia, he contended it was a nutrient-deficiency disease. Houston and others have followed in his steps with numerous valid arguments, including clinical reports from the 1930’s and 1940s of the benefits of thiocianate in sickle cell blood. In his seminal article in which he lays out the evidence, both epidemiological and biochemical, Houston reviews the literature describing how Jamaicans who have immigrated to the United States have developed sickle cell anemia, a genetic ‘disease’ of which they had not even been aware. When some of these Jamaican natives returned to their island (and to their native diets) the sickle cell anemia crises subsided completely. Foods containing thiocyanate compounds are vegetables from the brassica family such as cabbage and broccoli, the seeds of most fruits, flax seeds, bitter almonds, the grain millet, and some pulses (beans). Africans have food preparation customs which lower the cyanate content of their staples, the cassava and African yam (no relation with potato), to safe levels.
Although currently it is studied as a anti-cancer micronutrient, thiocyanate suffered a bad rap due to the fact that, on its metabolic path in the body, it turns into cyanide. However, pure cyanide, a molecule of carbon and one of nitrogen united by a triple bond, has existed long before any life form existed on Earth. Human body, and other vertebrates as well, can handle minute amounts of this highly poisonous substance. In fact cyanide has a role in the synthesis of vitamin B12. After making use of it, the body turns the cyanide back into thiocyanate with the help of the enzyme rhodanide synthetase. Sufficient protein intake is needed for this conversion to take place. Additonally, individuals who eat thiocyanate-rich foods have to supplement with iodine.
There are dozens of plants containing thiocyanate or various compounds of cyanide, and one pioneer in revealing their health-giving properties, Ernst T. Krebs, has called them nitrilosides. Krebs, who contended that thiocyanate should be accepted as a vitamin (B17), researched animal diets as a student of zoology and found that most animals, including those living at the North Pole, have a thiocyanate source in the diet.
Sickle cell patients were found to be clinical deficient in many micronutrients, including the amino acid Arginine, the minerals zinc, magnesium and the B vitamins. Some studies show that these and other nutrients such as fish oil, and a combination of folic acid, aged garlic, l-Arginine, vitamins E and C have had beneficial effects on the health of these patients. The mineral zinc, for example, was found to reduce leg ulcers, which are often associated with sickle cell anemia, while the mineral magnesium pidolate was found to reduce the crises.
One of the most staunch promoter of nutrition awareness among sickle cell patients, Berkeley nutritionist and health writer Clara Felix reported repeatedly on the sickle cell and thiocyanate connection in her newsletter, “The Felix Letter, A Commentary on Nutrition.” She kept track relentlessly of all the efforts towards research in this direction. She also has described the cold shoulder that she encountered when she tried to bring Oji Agbai and other thiocyanate promoters to the attention of clinical practitioners, specifically at the Children's Hospital in Oakland. Clara Felix so wanted that those children (from the sickle cell ward at Oakland Children Hospital for example) benefit from her passionate research. In her memory, her son Elliot, has founded a non profit sickle cell section in his acupuncture clinic (http://www.clarafelixclinic.
No comments:
Post a Comment